In recent years, Actos (Pioglitazone Hydrochloride), marketed by Glaxo Wellcome, has become the first-line therapy for type 2 diabetes, and the first FDA-approved drug for this condition. Its generic, Actos (pioglitazone hydrochloride), is a non-steroidal anti-inflammatory drug (NSAID). The mechanism of action of Actos is as follows:
This article will review the current clinical studies on Actos, its use in the treatment of Type 2 diabetes and how it compares to other available diabetes medications.
Actos is an oral medicine that is used in the treatment of Type 2 diabetes. It belongs to the family of medicines known as thiazolidinediones (TZD), a group of drugs that work by reducing the blood glucose level in the blood.
This medication is available in the form of a tablet.
The medication is usually taken by mouth once a day. It is taken with or without food to reduce stomach irritation.
The effectiveness of this medication is confirmed by studies that show it can treat Type 2 diabetes in patients with normal glucose tolerance.
The medication is available in the form of a pill.
The medication is used as an adjunct to diet and exercise to lower blood glucose levels in patients with type 2 diabetes. Actos has been approved by the FDA in the treatment of type 2 diabetes.
The medication is also used to treat bladder cancer. It has been approved by the FDA to be used as an adjuvant therapy in women with bladder cancer.
The medication works by blocking the action of two key proteins: GLP-1 and GLP-2.
GLP-1 is a hormone that regulates blood sugar levels. It helps control blood glucose levels by secreting insulin and reducing glucose uptake from the bloodstream. GLP-1 can be a therapeutic option for people with type 2 diabetes who have not responded to a diet and exercise alone.
The mechanism of action of Actos is to prevent the body from releasing a high-glycemic-index (glucose) sugar. This type of sugar is the result of the insulin-like growth factor-1 (IGF-1) that is produced when cells release these hormones. Glucose is then converted into glucose in the liver. When the body’s cells are destroyed, it reduces the sugar concentration in the bloodstream. This reduction is responsible for lowering blood glucose levels.
The medication is a non-steroidal anti-inflammatory drug (NSAID). It is available in the form of a tablet.
It is an orally available tablet, which is also available under the brand name Glaxo.
The medication works by reducing the production of the insulin-like growth factor-1, which is produced by the pancreas. This growth factor regulates the production of the hormone GLP-1. The medication is also used to treat type 2 diabetes.
There are no published studies on the use of Actos in patients with type 2 diabetes.
The use of Actos in patients with type 2 diabetes is controversial. Some experts believe that the medication is safe and has no adverse effects.
Other studies have also shown that Actos can be used for long periods of time without any adverse effects. It may be prescribed to patients with type 2 diabetes in the dose and duration that is needed, but the safety and efficacy of this drug in these patients cannot be proven.
1.1. Guidelines for the use of lactose-free milk for the treatment of lactose intolerance. The guideline recommends that children be given a milk source containing lactose (with or without milk). It also recommends that infants should be given a lactose-free milk diet.1
1.2. The guideline recommends that children be given a milk source containing lactose (with or without milk).2
2.1.1. Pre-study and clinical trial data.
2.1.2. Data regarding the safety of lactose-free milk for the treatment of lactose intolerance. The guideline recommends that infants should be given a milk source containing lactose (with or without milk).2
2.2. Recommendations for the use of lactose-free milk for the treatment of lactose intolerance.
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2.3.2.
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3.1.1.
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4.1.2. The guideline recommends that infants should be given a milk source containing lactose (with or without milk).4
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4.1.6.
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5.1.1.
5.1.2. The guideline recommends that infants should be given a milk source containing lactose (with or without milk).5
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Actos (pioglitazone) is indicated for the treatment of type 2 diabetes mellitus in adults. Actos is also indicated for the treatment of type 2 diabetes mellitus in children.
Actos is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Actos is also indicated for the treatment of benign prostatic hyperplasia (BPH) in patients with a previous diagnosis of enlarged prostates.
In clinical studies, the effectiveness of Actos was shown to be similar to that of metformin.
For patients who are unable to take oral diabetes medicine (eg, patients taking oral hypoglycemics) Actos can be taken once a day.
Actos is a registered US product.
Actos is a prescription drug.
Active ingredient: pioglitazone
Inactive ingredients: cornstarch, carboxymethylcellulose, crospovidone, dihydrate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, titanium dioxide, and stearyl alcohol.
Shelf life: 4 years
Dosage form: tablet, oral solution, liquid or tablet, tablet/gel, tablet/gel/diluent
Packaging: blister, film coated tablets, vial, syringe, syringe, vial
Brand Name: Actos
Generic name: pioglitazone
Inactive ingredients: cornstarch, carboxymethylcellulose, crospovidone, dihydrate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, titanium dioxide, and stearyl alcohol
Shelf life: 3 months
Packaging: blister, film coated tablets, vial, syringe, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe, vial, syringe
To use:Do not use: On children under 18 years of age
If you are pregnant or breast-feeding
If you are taking oral diabetes medicines:Do not take: On children under 18 years of age
Follow all directions on your prescription label and read all drug information contained within this leaflet. If you have any questions regarding this medication, ask your doctor or pharmacist for advice. The product information on this leaflet comes from Actos USP and is enclosed in a product insert that contains more information about Actos.
For use only. If your doctor has told you not to take Actos, you may use the patient information patient leaflet from the product package insert or patient information insert from Actos. Patient information is enclosed in the product leaflet. Keep out of reach of children and pets.
If your doctor has told you not to take oral diabetes medicines, you may use the vial of Actos from Actos USP. Do not take the vial of Actos if you are elderly. The patient leaflet from Actos can be found in the Patient Information Leaflet supplied by your package insert or patient information leaflet. If you are elderly and think you may be pregnant, breast-feeding, taking oral diabetes medicines, or if you are pregnant, or if you are breast-feeding, talk to your doctor or pharmacist before taking Actos.
The following article byDr. Marc Chaudri(Department of Pharmacy and Pharmaceutical Sciences, The University of Adelaide, Adelaide, Australia) discusses the following important points about Actos 30 mg tablet:
Actos tablets contain an active substance that increases insulin levels in the body. It is used to treat Type 1 Diabetes (T1D), Insulin Resistance (IR), High Blood Pressure (BP), and Obesity (BPH).
The use of Actos tablets is restricted to individuals with a BMI of 27 and a body mass index of 35–39 kg/m2 or less. Actos is a prescription medicine that can only be bought from a doctor or pharmacy. The doctor will not prescribe this medication unless the person has a valid prescription. The most common side effects of Actos include headaches, nausea, flushing, and upset stomach. It is essential to check the product label for any possible side effects or side effects not listed in the package. The most common side effects of Actos tablets are headache, stomach pain, nausea, abdominal pain, and a metallic taste in the mouth. If you experience any of these symptoms, stop taking this medication immediately and seek medical attention. However, if you have any questions or concerns, consult your doctor.
For more information about Actos, please visit the website:
Actos tablets are a type of medicine called a thiazolidinedione. A thiazolidinedione, like other drugs, can be divided into two main groups:
Group 1: a group of drugs that affect the metabolism of glucose and a group of drugs that affect insulin. When a medication is taken, it is absorbed into the bloodstream, and it can be used in the treatment of Type 1 diabetes.
Group 2: a group of drugs that affect the metabolism of fat and carbohydrates. When a medication is taken, it is absorbed into the bloodstream, and it can be used in the treatment of Type 2 diabetes.
The most common side effects of Actos tablets are headaches, nausea, flushing, and upset stomach.
Some side effects of Actos tablets are minor and not experienced by all people.
The following claims are made in theActos (Pioglitazone) Prescribing Informationsection.
1. The FDA has determined that Actos is a safe drug and the label for Actos may be used to label it as safe. The label for Actos should be read to include a warning that the drug may cause a serious condition. It should be noted that Actos is a prescription drug.
2. The labeling of Actos must be clear. The drug must be manufactured by a licensed company in a laboratory.
3. It should be reported on a regular basis to the FDA for approval in all medical offices, the laboratory, and the pharmacy to ensure a safe and effective product. The FDA may issue a label update to the drug and report back to the FDA for approval to ensure that the drug is approved to treat a similar condition.
4. It should be reported on a regular basis to the FDA for approval to ensure the drug is approved to treat a serious medical problem. The label must clearly state how the drug is to be used and how it will be effective. The FDA should have approved the drug for more than one condition in a given month. The FDA should report the FDA for approval to the National Library of Medicine for an online drug review.
5. The FDA will provide the following updates to the product information on the Actos label. These updates should be sent to the FDA for review and consideration. FDA may require additional information in the event of a problem with the drug and may adjust the labeling or recommend additional labeling changes.
6. The label will provide information about the drug. The label may include a list of all possible side effects. The label will provide the most recent information for the drug and will also provide information on the dosage and duration of treatment. The FDA will have the information on the label and may determine whether the drug should be used.
7. The label will be updated for the first year. In the event of a failure to meet the drug’s stated goals, the FDA may require that the drug be used in a more appropriate and effective way to treat the condition or alternative treatment option.
8. The label will be updated for the second year.
9. The label will be updated for the third year.
10. The label will be updated for the fourth year.
11. The label will be updated for the fifth year.
12. The label will be updated for the sixth year.
13. The label will be updated for the seventh year.
14. The label will be updated for the eighth year.
15. The label will be updated for the ninth year.
16. The label will be updated for the tenth year.
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